NK CELL DEPLETION IN BISPECIFIC ANTIBODY THERAPY IS ASSOCIATED WITH LACK OF HIV CONTROL AFTER ART INTERRUPTION

NK cell depletion in bispecific antibody therapy is associated with lack of HIV control after ART interruption

Abstract HIV infection remains incurable as the virus persists within a latent reservoir of CD4+T cells.Novel approaches to enhance immune responses against HIV are essential for effective control and potential cure of the infection.In this study, we designed a novel tetravalent bispecific antibody (Bi-Ab32/16) to simultaneously target the gp120 vi

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Reduced tyrosine kinase inhibitor dose is predicted to be as effective as standard dose in chronic myeloid leukemia: a simulation study based on phase III trial data

Continuing tyrosine kinase inhibitor (TKI)-mediated targeting of the BCR-ABL1 oncoprotein is the standard therapy for chronic myeloid leukemia (CML) and allows for a sustained disease control in the majority of patients.While therapy cessation for patients appeared as a safe option for about half of those patients with optimal response, no systemat

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The Case for Nonlocal Modifications of Gravity

The huge amounts Mittens of undetected and exotic dark matter and dark energy needed to make general relativity work on large scales argue that we should investigate modifications of gravity.The only stable, metric-based and invariant alternative to general relativity is f(R) models.These models can explain primordial inflation, but they cannot dis

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